Dr.Anila Mathew Profile

Dr. Anila Mathew

Bio-Nano Electronics Research Center,
Toyo University,
2100 Kujirai, Kawagoe shi,
Saitama ken, Japan 350 8585
Tel: +81- (0) 492-39- 1375
Fax: +81-(0) 492-34-2502

Academic Profile:

Doctor of Life Science in Bio-Nano Science Fusion from Toyo University, Kawagoe, Japan (2009-2012).
Master of Science in Biotechnology (2004-2006)
Advanced Diploma in Bioinformatics (2005-2006)
Bachelor of Science in Biotechnology (2001-2004)

Professional History

Post-doctoral researcher in Department of Materials and Applied Chemistry, Nihon University, Tokyo, Japan (2012-2013).
Research Assistant in Human Molecular Genetics Laboratory, Rajiv Gandhi Center for Biotechnology (2007-2009).
Guest lecturer in Department of Biotechnology, J.D.T Islam College of Arts and Science, Calicut (2006-2007).

Other Achievements

Recipient of Japanese Government Monbukagusho - MEXT Scholarship (2009-2012).
Qualified the NET (National Eligibility Test -Lectureship) 2007 December exam conducted jointly by the CSIR and UGC, Government of India.
Qualified GATE (Graduate Aptitude Test in Engineering) 2007 with score 341 and all India rank 1415.

Research Interests

Title of the thesis: Synthesis and characterization of targeted nano-regulators as potential therapeutic agents for controlling Alzheimer's disease

Link to the presentation:

http://webedu.sce.toyo.ac.jp/bionanosci/Viewer/?peid=14ca004229a94931b3001bfe7b6a79de

Thesis Outline:

With the increase in the aged population, Alzheimer's disease is becoming a serious problem all over the world. The currently available drugs are not very promising and the multifactorial nature of the disease makes the therapeutic efficacy very less. Curcumin is a versatile compound with various therapeutic properties including anti-amyloid property. Apart from this, anti-oxidative property of curcumin can also be beneficial when considering Alzheimer therapy. But the use of curcumin remains limited in medical applications due to its hydrophobicity and insolubility in water. We have overcome this with the synthesis of water-soluble Poly (lactic-co-glycolic acid) (PLGA) coated-curcumin nanoparticles. PLGA was chosen for enabling nanoparticle synthesis due to its biocompatible and biodegradable nature. We have found that curcumin encapsulation by PLGA does not change any of its inherent properties. We have also studied the cytotoxicity profile of the nanoparticles and have found that the curcumin-PLGA nanoparticles are highly biocompatible. The synthesized nanoparticles are modified in two different ways for potential use in Alzheimer's- one by conjugating it with neuronal targeting Tet-1 peptide with retrograde axonal transportation property and the second method by conjugating it with amyloid-binding aptamer to facilitate plasma amyloid binding activity. The Tet-1 conjugated nanoparticles exhibit higher neuronal uptake and can be used for targeting neuronal cells. The amyloid-binding aptamer enables the reduction of plasma amyloid in Alzheimer patients. We have found that the Tet-1 attachment and the aptamer attachment does not change the anti-amyloid and anti-oxidative properties of curcumin. We propose that the synergistic activity of these modified nanoparticles can be used in decreasing the amyloid load in Alzheimer patients, and thus help in ameliorating the Alzheimer's disease progression.

Publications:

Kamimiya H, Suzuki Y, Mathew A, Kabayama K et al., (2013)
Simple and rapid removal of the interference in gangliosides extracted from HPTLC spot on MALDI-TOF MS analysis. Analytical Methods DOI: 10.1039/C3AY41011K.
Mathew A, Fukuda T, Nagaoka Y, Hasumura T, Morimoto H, et al. (2012)
Curcumin loaded- PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's Disease. PLoS ONE 7(3): e32616.DOI: i:10.1371/journal.pone.0032616.
Vijayan NN, Mathew A, Balan S, Natarajan C, Nair CM, Allencherry PM, Banerjee M (2012)
Antipsychotic drug usage and therapeutic response in schizophrenia is influenced by ABCB1 genotypes: a study from a south Indian perspective. Pharmacogenomics 13(10).
Mathew A, Aravind A, Brahatheeswaran D, Fukuda T, Nagaoka Y, et al. (2012)
Amyloid-binding aptamer conjugated curcumin-PLGA nanoparticle for potential use in Alzheimer's Disease. Bionanoscience 2(2): 83-93. DOI: 10.1007/s12668-012-0040-y.
AravindA, VargheeseSH, Veeranarayan S, Mathew A, Nagaoka Y, et al., (2012)
Aptamer-labeled PLGA nanoparticle for cancer therapy. Cancer Nanotechnology DOI: 10.1007/s12645-011-0024-6.
Brahatheeswaran D, Mathew A, Aswathy RG, Nagaoka Y, Venugopal K, et al., (2012)
Hybrid fluorescent curcumin loaded zeinelectrospunnanofibrous scaffold for biomedical applications. Biomedical Materials 7(4) DOI: 10.1088/1748-6041/7/4/045001.
Mathew A, Yoshida Y, Maekawa T, Kumar DS (2011)
Alzheimer's Disease: Cholesterol a menace? Brain Research Bulletin 86 (1-2) pp. 1-12. (Listed in the 'Most read top 10' of the journal in the second half of 2011).
Mathew A, Aravind A, Fukuda T, Hasumura T, Nagaoka Y, et al., (2011)
Curcumin nanoparticles- a gateway for multifaceted approach to tackle Alzheimer's Disease. 2011 11th IEEE International Conference on Nanotechnology pp. 833-866.
Das A, Balan S, Mathew A, Radhakrishnan V, Banerjee M, Radhakrishnan K (2011)
Corpora amylacea deposition in the hippocampus of patients with mesial temporal lobe epilepsy: A new role for an old gene? Indian Journal of Human Genetics 17(1) pp. 41-47.
Vahab SA, Sen S, Ravindran N, Mony S, Mathew A, Vijayan N, et al., (2009)
Analysis of genotype and haplotype effects of ABCB1 (MDR1) polymorphisms in the risk of medically refractory epilepsy in an Indian population. Drug metabolism and pharmacokinetics Vol. 24 No 3 pp. 255-260.
Natarajan C, Neetha NV, Linda KV, Mathew A, SrinivasL,Banerjee M(2008)
Universal Protocol for Generating 100bp Size Standard for Endless Usage. Electronic Journal of Biotechnology (online) 15 April 2008, vol. 11, no. 2.

Book Chapter:

Aravind A*, Mathew A*, D. Sakthi Kumar (* equal contribution) (2012) Nano - Based Aptamers Mediated Imaging and Drug Delivery in Cancer in "Biomedical Applications of Aptamers" by Nova Publishers.Editors: John Bruno (Operational Technologies Corp., San Antonio, TX).

Oral Presentations:

Mathew A, Kato K, VenugopalK, Maekawa T, Kumar DS, Therapeutic effects of curcumin-loaded and anti-body targeted nanoparticle in gastric cancer. 8th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT), Granada, Spain, September 24th, 2013.
Mathew A, Nanotechnology and applications with special focus on drug discovery and development. Providence Women`s College, Calicut, India. March 6th, 2012.
Mathew A, Aravind A, Fukuda T, Hasumura T, Nagaoka Y, et al., (2011) Curcumin nanoparticles for treating Alzheimer's Disease- A way of herbal renaissance (Oral and poster presentation). India- Japan Symposium on Health and Environment, Tokyo, Japan. October 7th, 2011.
Mathew A, Aravind A, Fukuda T, Hasumura T, Nagaoka Y, et al., (2011) Curcumin nanoparticles- a gateway for multifaceted approach to tackle Alzheimer's Disease. 2011 11th IEEE International Conference on Nanotechnology (pp. 833-866), Portland (OR), USA. August 17th , 2011.

Conferences:

Mathew A, Venugopal K, Maekawa T, Kumar DS, Synthesis and characterization of targeted nano-regulators as potential therapeutic agents in Alzheimer’s Disease. 8th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT), Granada, Spain, September 24th, 2013.
Mathew A, Aravind A, Fukuda T, et al., (2011) Curcumin nanoparticles- a gateway for multifaceted approach to tackle Alzheimer’s Disease. 11th IEEE International Conference on Nanotechnology, Portland, USA.pp. 833-866.
Mathew A,Jose M, Neetha NV, Linda KV, et al., (2008) Investigating the Role of Polymorphisms in MDR1 and MTHFR with Teratogenicity of Antiepileptic Drugs. Human Genome Organization’s 13th Human Genome Meeting, India. Page 187, Poster 366.
Mathew A, Das A, Ram PP, et al., (2007) Impact of MDR1 Haplotype Bearing C3435T Polymorphism in Medically Refractory Mesial Temporal Lobe Epilepsy Patients from Kerala. International Symposium on Dissecting the Role of Genes and Environment in Complex Diseases, Centre for Cellular and Molecular Biology, India. Page P-1, Poster 1.